C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding
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چکیده
منابع مشابه
C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding
The soluble interleukin 6 receptor (sIL-6R) circulates at elevated levels in various diseases. This suggests that inflammatory mediators control sIL-6R release. Through examination of human neutrophils, it was found that the acute phase reactant C-reactive protein (CRP) activates a threefold increase in sIL-6R production. Maximal release occurred after 30-60 min exposure to CRP (50 micrograms/m...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1999
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.189.3.599